Swift jjewel 3d world atlas
Uzel went on to explain that “the idea of this SWIFT printing process really took shape when we speculated that once jammed into a dense slurry, those organoids would behave as predicted by the science of colloid suspensions and therefore could serve as a supporting living matrix for the free form templating of perfusable vessels. They are cellularly dense and exhibit great functional and architectural similarities with the organs they are meant to mimic.”Ī branching network of channels of red, gelatin-based “ink” is 3D printed into a living cardiac tissue construct composed of millions of cells (yellow) using a thin nozzle to mimic organ vasculature. “Using patient-derived organoids or 3D cell spheroids as our building blocks appeared like a natural choice. “Inspired by the 3D bioprinting techniques emerging from the Lewis lab and the community in general, Mark and I decided that is was time to tackle, head-on, the challenge of cell function and density, and tissue volume, which were keeping us from reaching organ manufacturing at therapeutic scale,” revealed Uzel. Two weeks ago, went into some of the main details of the research, but now we have gone straight to the source and spoken with two of the co-first authors of the paper, which came out on September 6 in Science Advances, to understand the process behind the method, as well as the collaborative work shaping the future of Harvard’s bioengineering aspirations. This is where the SWIFT method comes into play, 3D printing vascular channels into living tissues.
The method, called SWIFT (sacrificial writing into functional tissue), allows 3D printing to focus on creating the vessels necessary to support a living tissue construct.Īll organs need blood vessels to supply their cells with nutrients, but most lab-grown organoids lack a supportive vasculature.
Paulson School of Engineering and Applied Sciences (SEAS), came up with a breakthrough new technique that could one day provide organ tissues for therapeutic use. A few weeks ago, Mark Skylar-Scott and Sébastien Uzel, researchers working in Jennifer Lewis’ Lab at Harvard´s Wyss Institute for Biologically Inspired Engineering and John A.